GLI2 anticorps (AA 46-1398)

N° du produit ABIN7875109

Cet anticorps anti-GLI2 Polyclonal Lapin (ABIN7875109) détecte spécifiquement GLI2 dans WB, ELISA, IHC (p), IF et FACS. L’anticorps est réactif avec des échantillons de Humain et Rat.

Aperçu rapide pour GLI2 anticorps (AA 46-1398) (ABIN7875109)

Antigène: GLI2 (GLI Family Zinc Finger 2 (GLI2))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GLI2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-GLI2 anticorps

Épitope: AA 46-1398

Fonction: GLI2 Antibody / GLI family zinc finger protein 2

Purification: Antigen affinity purified

Immunogène: An E.coli-derived human recombinant protein (A46-A1398) was used as the immunogen for the GLI2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the GLI2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the GLI2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur GLI2

Antigène: GLI2 (GLI Family Zinc Finger 2 (GLI2))

Autre désignation: GLI2

Sujet: GLI2 (Gli-Kruppel Family Member 2), also called ONCOGENE GLI2, is a protein that in humans is encoded by the GLI2 gene. Sequencing of GLI cDNA clones showed the presence of 5 tandem zinc fingers connected by histidine-cysteine links, which indicated that the gene belongs to the family of zinc finger genes related to Kruppel (Kr). The Drosophila gene Kr is a member of the gap class of segmentation genes, thoracic and anterior abdominal segments fail to form in Kr mutant embryos. By fluorescence in situ hybridization, Matsumoto et al. (1996) refined the assignment of the GLI2 gene to chromosome 2q14. Roessler et al. (2005) showed that GLI2-delta-N exhibited potent transcriptional activity in vivo: overexpression in mouse skin led to the formation of hedgehog-independent epithelial downgrowths resembling basal cell carcinomas, which in humans are associated with constitutive hedgehog signaling.

UniProt: P10070

Pathways: Signalisation Hedgehog, Dopaminergic Neurogenesis