Recombinant BAP1 anticorps (AA 500-729)

N° du produit ABIN7875474

L’anticorps anti-BAP1 Monoclonal Lapin est utilisé pour la détection de BAP1 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour Recombinant BAP1 anticorps (AA 500-729) (ABIN7875474)

Antigène: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp BAP1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: BAP1-9120R

Détail du produit anti-BAP1 anticorps

Épitope: AA 500-729

Fonction: Recombinant BRCA1-Associated Protein 1 Antibody / BAP1

Purification: Protein A/G affinity

Immunogène: A recombinant fragment (within amino acids 500-729) of human BAP1 protein was used as the immunogen for the recombinant BRCA1-Associated Protein 1 antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant BRCA1-Associated Protein 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the recombinant BRCA1-Associated Protein 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur BAP1

Antigène: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Autre désignation: BRCA1-Associated Protein 1

Sujet: The BAP1 gene belongs to the ubiquitin C-terminal hydrolase subfamily of de-ubiquitination enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germ line mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, Uveal melanoma and cutaneous melanoma.

UniProt: Q92560