Stanniocalcin 2 anticorps (AA 51-226)

N° du produit ABIN7875514

Cet anticorps anti-Stanniocalcin 2 Polyclonal Lapin (ABIN7875514) détecte spécifiquement Stanniocalcin 2 dans WB, IHC, ELISA, ICC, IF et FACS. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Stanniocalcin 2 anticorps (AA 51-226) (ABIN7875514)

Antigène: Stanniocalcin 2 (STC2)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Stanniocalcin 2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-Stanniocalcin 2 anticorps

Épitope: AA 51-226

Fonction: STC2 Antibody / Stanniocalcin 2

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human Stanniocalcin 2/STC2 recombinant protein (Position: A51-Q226) was used as the immunogen for the STC2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the STC2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the STC2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Stanniocalcin 2

Antigène: Stanniocalcin 2 (STC2)

Autre désignation: STC2

Sujet: STC2 antibody detects Stanniocalcin 2, encoded by the STC2 gene. Stanniocalcin 2 is a secreted glycoprotein hormone involved in calcium and phosphate homeostasis, cell metabolism, and stress responses. STC2 antibody provides researchers with a reliable reagent for studying calcium signaling, endocrine function, and cancer biology.

Stanniocalcin 2 belongs to a family of hormones originally described in fish for regulating calcium uptake in gills, but in mammals it plays broader roles. Research using STC2 antibody has shown that it is widely expressed in endocrine and metabolic tissues, including kidney, pancreas, and liver. It regulates calcium and phosphate transport by modulating ion channels and transporters, ensuring mineral balance and bone health.

Studies with STC2 antibody have revealed that Stanniocalcin 2 is upregulated in response to hypoxia and endoplasmic reticulum stress. As a stress-responsive hormone, STC2 promotes cell survival by inhibiting apoptosis and supporting adaptation to metabolic stress. This function links STC2 to cancer and ischemic disease, where stress responses are critical.

In oncology, Stanniocalcin 2 has been associated with tumor progression. Research using STC2 antibody has demonstrated that elevated STC2 expression correlates with metastasis, angiogenesis, and resistance to chemotherapy in breast, liver, and colorectal cancers. By regulating calcium signaling and stress pathways, tumors exploit STC2 to enhance survival and growth. This makes it a potential biomarker and therapeutic target.

STC2 antibody is widely applied in western blotting, immunohistochemistry, and ELISA. Western blotting quantifies protein levels, immunohistochemistry reveals expression in normal and cancer tissues, and ELISA measures circulating hormone levels in serum samples. These approaches make STC2 antibody a valuable tool for both basic and clinical research.

By providing validated STC2 antibody reagents, NSJ Bioreagents supports studies into mineral metabolism, stress signaling, and disease. Detection of Stanniocalcin 2 provides researchers with insight into how endocrine hormones regulate physiology and pathology.

UniProt: O76061

Pathways: Hormone Activity, ER-Nucleus Signaling, SARS-CoV-2 Protein Interactome