ACTN2 anticorps (AA 557-692)

N° du produit ABIN7875737

Cet anticorps Souris Monoclonal détecte spécifiquement ACTN2 dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour ACTN2 anticorps (AA 557-692) (ABIN7875737)

Antigène: ACTN2 (Actinin, alpha 2 (ACTN2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ACTN2 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: ACTN2-3291

Détail du produit anti-ACTN2 anticorps

Épitope: AA 557-692

Fonction: ACTN2 Antibody / Alpha Actinin 2 / Sarcomeric Alpha Actinin

Purification: Protein G affinity chromatography

Immunogène: Amino acids 557-692 from the human protein were used as the immunogen for this ACTN2 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the ACTN2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the ACTN2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur ACTN2

Antigène: ACTN2 (Actinin, alpha 2 (ACTN2))

Autre désignation: ACTN2

Sujet: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In non-muscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.

UniProt: P35609

Pathways: Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Negative Regulation of Transporter Activity