CD86 anticorps (AA 66-195)

N° du produit ABIN7876328

Cet anticorps Souris Monoclonal détecte spécifiquement CD86 dans WB et IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour CD86 anticorps (AA 66-195) (ABIN7876328)

Antigène: CD86

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD86 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: C86-3711

Détail du produit anti-CD86 anticorps

Épitope: AA 66-195

Fonction: CD86 Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: A portion of amino acids 66-195 from the human protein was used as the immunogen for the CD86 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the CD86 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the CD86 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur CD86

Antigène: CD86

Autre désignation: CD86

Sujet: Recognizes a protein of 70 kDa, which is identified as CD86. CD86 is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. CD86 expression is rapidly upregulated by B cell specific stimuli with peak expression at 18 to 42 hours after stimulation. CD86, along with CD80/B71, is an important accessory molecule in T cell co-stimulation via its interaction with CD28 and CD152/CTLA4. Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response. It is also found on malignant Hodgkin and Reed Sternberg (HRS) cells in Hodgkins disease.

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation