FLT3 anticorps (AA 66-993)

N° du produit ABIN7876357

Cet anticorps anti-FLT3 Polyclonal Lapin (ABIN7876357) détecte spécifiquement FLT3 dans WB, ELISA et IHC (p). L’anticorps est réactif avec des échantillons de Humain et Rat.

Aperçu rapide pour FLT3 anticorps (AA 66-993) (ABIN7876357)

Antigène: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FLT3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-FLT3 anticorps

Épitope: AA 66-993

Fonction: CD135 Antibody / FLT3

Purification: Antigen affinity purified

Immunogène: Recombinant human protein (amino acids A66-S993) was used as the immunogen for the CD135 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the CD135 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the CD135 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur FLT3

Antigène: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Autre désignation: CD135

Sujet: Cluster of differentiation antigen 135 (CD135) also known as fms like tyrosine kinase 3 (FLT-3), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 gene. This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

UniProt: P36888

Pathways: Signalisation RTK