Nestin anticorps (AA 698-844)

N° du produit ABIN7876460

Cet anticorps Souris Monoclonal détecte spécifiquement Nestin dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Nestin anticorps (AA 698-844) (ABIN7876460)

Antigène: Nestin (NES)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Nestin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: NES-2911

Détail du produit anti-Nestin anticorps

Épitope: AA 698-844

Fonction: Nestin Antibody

Purification: Protein G affinity chromatography

Immunogène: A recombinant human partial protein (amino acids 698-844) was used as the immunogen for the Nestin antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Nestin antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Nestin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Nestin

Antigène: Nestin (NES)

Autre désignation: Nestin

Sujet: Nestin is a major intermediate filament (IF) protein of embryonic central nervous system progenitor cells. It is also a component of the dynamic IF network during muscle development, where it polymerizes with Desmin and Vimentin. Nestin co-assembles with Vimentin or -internexin and forms heterodimer coiled-coil molecules which then further assemble into 10 nml IFs. Deletion of the IF consensus rod domain in nestin alters nestin localization in CNS precursor cells and radial glial cells in vivo. Nestin is a marker for neuroepithelial stem cells, glioma cells and tumor endothelial cells during rapid growth. During axon elongation of differentiation neurons, nestin localizes to the growth cones and may play a role in growth cone guidance. In the rat adrenal gland, nestin is expressed by the zona fasciculata and the zona reticularis. Nestin is also expressed by dermatomal cells and by myoblasts during the earliest stages of myogenesis.

UniProt: P48681