LDLR anticorps (AA 705-860)

N° du produit ABIN7876593

L’anticorps anti-LDLR Polyclonal Lapin est utilisé pour la détection de LDLR dans des échantillons de Humain. Il a été validé pour WB, ELISA et FACS.

Aperçu rapide pour LDLR anticorps (AA 705-860) (ABIN7876593)

Antigène: LDLR (Low Density Lipoprotein Receptor (LDLR))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LDLR est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-LDLR anticorps

Épitope: AA 705-860

Fonction: LDLR Antibody / LDL Receptor

Purification: Antigen affinity purified

Immunogène: E. coli-derived recombinant human protein (amino acids A705-A860) was used as the immunogen for the LDLR antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the LDLR antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the LDLR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur LDLR

Antigène: LDLR (Low Density Lipoprotein Receptor (LDLR))

Autre désignation: LDLR

Sujet: In humans, the LDL receptor protein is encoded by the LDLR gene on chromosome 19. It is mapped to 19p13.2. The low absorbance lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low absorbance lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

UniProt: P01130

Pathways: Hepatitis C, Lipid Metabolism