INPP5D anticorps (AA 81-1093)

N° du produit ABIN7876881

L’anticorps anti-INPP5D Polyclonal Lapin est utilisé pour la détection de INPP5D dans des échantillons de Humain. Il a été validé pour WB, ELISA et FACS.

Aperçu rapide pour INPP5D anticorps (AA 81-1093) (ABIN7876881)

Antigène: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp INPP5D est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-INPP5D anticorps

Épitope: AA 81-1093

Fonction: INPP5D Antibody / Inositol polyphosphate-5-phosphatase D / SHIP1

Purification: Antigen affinity purified

Immunogène: An E.coli-derived human recombinant protein (amino acids Q81-E1093) was used as the immunogen for the INPP5D antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the INPP5D antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the INPP5D antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur INPP5D

Antigène: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Autre désignation: INPP5D

Sujet: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 is an enzyme that in humans is encoded by the INPP5D gene. This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system.

UniProt: Q92835

Pathways: TCR Signaling, BCR Signaling, L'effet Warburg