Ephrin A1 anticorps (AA 83-115)

N° du produit ABIN7876931

Cet anticorps Souris Polyclonal détecte spécifiquement Ephrin A1 dans WB et IF. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Ephrin A1 anticorps (AA 83-115) (ABIN7876931)

Antigène: Ephrin A1 (EFNA1)

Reactivité: Humain

Hôte: Souris

Clonalité: Polyclonal

Conjugué: Cet anticorp Ephrin A1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-Ephrin A1 anticorps

Épitope: AA 83-115

Fonction: EFNA1 Antibody / Ephrin A1

Immunogène: A portion of amino acids 83-115 from the human protein was used as the immunogen for the EFNA1 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the EFNA1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide and 50 % glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the EFNA1 antibody at -20oC.

Détails sur Ephrin A1

Antigène: Ephrin A1 (EFNA1)

Autre désignation: EFNA1

Sujet: Ephrin A1 is a membrane-bound protein that interacts with Eph receptors on neighboring cells, initiating a cascade of signals that regulate cell behavior and movement. This interaction is essential for processes such as cell migration, tissue organization, and synaptic connectivity in the nervous system. Studies have shown that dysregulation of Ephrin A1 signaling can lead to aberrant cell growth, invasion, and metastasis in cancer cells, highlighting its importance in disease progression. One of the key features of Ephrin A1 is its ability to both attract and repel cells, depending on the context and concentration of the molecule. This dual role allows Ephrin A1 to fine-tune cell-cell interactions and ensure proper tissue patterning during development. In the brain, for example, Ephrin A1 guides axonal growth and synapse formation, shaping the intricate neural circuits that underlie cognitive functions. In addition to its role in development, Ephrin A1 has also been implicated in several disease processes. Aberrant expression of EFNA1 has been observed in various types of cancer, including breast, lung, and colon cancer, where it promotes tumor growth and invasion. In neurodegenerative disorders such as Alzheimer's disease, dysregulation of Ephrin A1 signaling disrupts synaptic connectivity and contributes to cognitive decline.

UniProt: P20827

Pathways: Signalisation RTK