ECSIT anticorps (AA 83-339)

N° du produit ABIN7876939

Cet anticorps anti-ECSIT Polyclonal Lapin (ABIN7876939) détecte spécifiquement ECSIT dans WB, ELISA, IHC (p), IF et FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour ECSIT anticorps (AA 83-339) (ABIN7876939)

Antigène: ECSIT

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ECSIT est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-ECSIT anticorps

Épitope: AA 83-339

Fonction: ECSIT Antibody

Purification: Antigen affinity purified

Immunogène: Recombinant human protein (amino acids E83-S339) was used as the immunogen for the ECSIT antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the ECSIT antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the ECSIT antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur ECSIT

Antigène: ECSIT

Autre désignation: ECSIT

Sujet: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (ECSIT), also known as SITPEC, is a protein that in humans is encoded by the ECSIT gene. Activation of NF-kB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 to kinases such as IRAK and other intermediates such as TNF receptor associated factor (TRAF)-6. ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF)-6 in the TLR pathway. Recently however, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis, indicating the possibility of cross-talk between the TLR/IL-B and Bmp signaling pathways.

UniProt: Q9BQ95

Pathways: Signalisation TLR, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interactome