Aurora Kinase B anticorps (AA 89-251)

N° du produit ABIN7877050

Cet anticorps anti-Aurora Kinase B Monoclonal Souris (Clone AURKB-1845) (ABIN7877050) détecte spécifiquement Aurora Kinase B dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Aurora Kinase B anticorps (AA 89-251) (ABIN7877050)

Antigène: Aurora Kinase B (AURKB)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Aurora Kinase B est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: AURKB-1845

Détail du produit anti-Aurora Kinase B anticorps

Épitope: AA 89-251

Fonction: Aurora B Antibody / AURKB

Purification: Protein G affinity chromatography

Immunogène: A recombinant human protein fragment (amino acids 89-251) was used as the immunogen for this Aurora B antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Aurora B antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Aurora B antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Aurora Kinase B

Antigène: Aurora Kinase B (AURKB)

Autre désignation: Aurora B

Sujet: Recognizes a protein of 39 kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.

UniProt: Q96GD4

Pathways: TCR Signaling, Cycle Cellulaire, Maintenance of Protein Location, Hepatitis C, Toll-Like Receptors Cascades