NOD1 anticorps (AA 923-951)

N° du produit ABIN7877174

Cet anticorps Lapin Polyclonal détecte spécifiquement NOD1 dans WB et IHC (p). Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour NOD1 anticorps (AA 923-951) (ABIN7877174)

Antigène: NOD1 (Nucleotide-Binding Oligomerization Domain Containing 1 (NOD1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NOD1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-NOD1 anticorps

Épitope: AA 923-951

Fonction: NOD1 Antibody

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 923-951 from the human protein was used as the immunogen for the NOD1 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the NOD1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the NOD1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur NOD1

Antigène: NOD1 (Nucleotide-Binding Oligomerization Domain Containing 1 (NOD1))

Autre désignation: NOD1

Sujet: This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined.

UniProt: Q9Y239

Pathways: Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades, Inflammasome