Recombinant TARDBP anticorps (C-Term)

N° du produit ABIN7877486

Cet anticorps Lapin Monoclonal détecte spécifiquement TARDBP dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant TARDBP anticorps (C-Term) (ABIN7877486)

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp TARDBP est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TARDP-9299R

Détail du produit anti-TARDBP anticorps

Épitope: C-Term

Fonction: Recombinant TDP43 Antibody / TARDBP / TAR DNA binding protein

Purification: Protein A/G affinity

Immunogène: A recombinant fragment within human TDP43 aa 200 to the C-terminus was used as the immunogen for the recombinant TDP43 antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant TDP43 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the recombinant TDP43 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur TARDBP

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Autre désignation: TDP43

Sujet: TARDBP (TAR DNA binding protein), also known as TDP-43, is a nuclear protein that contains two RRM (RNA recognition motif) domains. Ubiquitously expressed with highest levels found in placenta, lung, pancreas, spleen and genital tract, TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. TARDBP can also function as a negative regulator of splicing activity and is known to be involved in the splicing of CFTR (cystic fibrosis transmembrane receptor). In addition, TARDBP is a major component of ubiquitin-positive inclusion bodies that are prominent in many neurodegenerative diseases. This suggests that TARDBP may play a role in the development of neurodegenerative disorders. Due to alternative splicing events, various isoforms exist for TARDBP.

UniProt: Q13148

Pathways: Positive Regulation of Peptide Hormone Secretion