Cyclin B2 anticorps (full length)

N° du produit ABIN7878064

Cet anticorps anti-Cyclin B2 Monoclonal Souris (Clone X29-2) (ABIN7878064) détecte spécifiquement Cyclin B2 dans ELISA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Cyclin B2 anticorps (full length) (ABIN7878064)

Antigène: Cyclin B2 (CCNB2)

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Cyclin B2 est non-conjugé

Application: ELISA

Classe de qualité: Carrier-free

Clone: X29-2

Détail du produit anti-Cyclin B2 anticorps

Épitope: full length

Fonction: Cyclin B2 Antibody / CCNB2 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: Recombinant full-length Xenopus laevis Cyclin B2 protein was used as the immunogen for this Cyclin B2 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Cyclin B2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Cyclin B2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Cyclin B2

Antigène: Cyclin B2 (CCNB2)

Autre désignation: Cyclin B2

Sujet: In eukaryotic cells, mitosis is initiated following the activation of a protein kinase known variously as maturation-promoting factor, M phase specific histone kinase or M-phase kinase. This protein kinase is composed of a catalytic subunit (Cdc2), a regulatory subunit (cyclin B) and a low molecular weight subunit (p13-Suc1). The Cdc/cyclin enzyme is subject to multiple levels of control, of which the regulation of the catalytic subunit by tyrosine phosphorylation is the best understood. Tyrosine phosphorylation inhibits the Cdc2/ cyclin B enzyme, and tyrosine dephosphorylation, occurring at the onset of mitosis, directly activates the pre-MPF complex. Evidence has established that B type cyclins not only act on M phase regulatory subunits of the Cdc2 protein kinase, but also activate the Cdc25A and Cdc25B endogenous tyrosine phosphatase, of which Cdc2 is the physiological substrate. The two B type cyclins, cyclin B1 and cyclin B2, have been shown to have distinct tissue distributions.

UniProt: O95067

Pathways: Cycle Cellulaire, M Phase