CDKN1B anticorps (full length)

N° du produit ABIN7878072

L’anticorps anti-CDKN1B Monoclonal Souris est utilisé pour la détection de CDKN1B dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour CDKN1B anticorps (full length) (ABIN7878072)

Antigène: CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CDKN1B est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: KIP1-1357

Détail du produit anti-CDKN1B anticorps

Épitope: full length

Fonction: p27Kip1 Antibody / p27 / CDKN1B (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human CDKN1B protein was used as the immunogen for the p27Kip1 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the p27Kip1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the p27Kip1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur CDKN1B

Antigène: CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))

Autre désignation: p27Kip1

Sujet: This MAb recognizes a 27 kDa protein, identified as the p27Kip1, a cell cycle regulatory mitotic inhibitor. It functions as a negative regulator of G1 progression and has been proposed to function as a possible mediator of TGF-b induced G1 arrest. p27Kip1 is a candidate tumor suppressor gene. Reportedly, low p27 expression has been associated with unfavorable prognosis in renal cell carcinoma, colon carcinoma, breast carcinomas, non-small-cell lung carcinoma, hepatocellular carcinoma, multiple myeloma, and lymph node metastases in papillary carcinoma of the thyroid, as well as a more aggressive phenotype in carcinoma of the cervix.

UniProt: P46527

Pathways: Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagy