POLE3 anticorps (full length)

N° du produit ABIN7878827

Cet anticorps Souris Monoclonal détecte spécifiquement POLE3 dans IF, FACS et ELISA. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour POLE3 anticorps (full length) (ABIN7878827)

Antigène: POLE3 (Polymerase (DNA Directed), epsilon 3 (p17 Subunit) (POLE3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp POLE3 est non-conjugé

Application: Immunofluorescence (IF), Flow Cytometry (FACS), ELISA

Classe de qualité: Carrier-free

Clone: PCRP-POLE3-3D3

Détail du produit anti-POLE3 anticorps

Épitope: full length

Fonction: CHRAC17 Antibody / POLE3 (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human POLE3 protein was used as the immunogen for the CHRAC17 antibody.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal dilution of the CHRAC17 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the CHRAC17 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur POLE3

Antigène: POLE3 (Polymerase (DNA Directed), epsilon 3 (p17 Subunit) (POLE3))

Autre désignation: CHRAC17

Sujet: DNA replication is initiated by the binding of initiation factors to the origin of replication. Nucleosomes inhibit access to the replication machinery at these origin sequences. Nucleosome remodeling factors increase the accessibility of nucleosomal DNA to transcriptional regulators. CHRAC15 and CHRAC17 are subunits of the nucleosomal remodeling factor CHRAC (chromatin accessibility complex), which increases the accessibility of nucleosomal DNA in an ATP-dependent manner. Unlike other known chromatin remodeling factors, CHRAC also functions during chromatin assembly by using ATP to convert irregular chromatin into a regular array of nucleosomes with even spacing. This conversion process occurs when CHRAC organizes randomly deposited histones into a regularly spaced array. In the presence of CHRAC, the nucleosomal ATPase ISWI catalyzes several ATP-dependent transitions of chromatin structure.

UniProt: Q9NRF9

Pathways: Réparation de l'ADN