POLE3 anticorps (full length)

N° du produit ABIN7878828

L’anticorps anti-POLE3 Monoclonal Souris est utilisé pour la détection de POLE3 dans des échantillons de Humain. Il a été validé pour IF, FACS et ELISA.

Aperçu rapide pour POLE3 anticorps (full length) (ABIN7878828)

Antigène: POLE3 (Polymerase (DNA Directed), epsilon 3 (p17 Subunit) (POLE3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp POLE3 est non-conjugé

Application: Immunofluorescence (IF), Flow Cytometry (FACS), ELISA

Clone: PCRP-POLE3-3D3

Détail du produit anti-POLE3 anticorps

Épitope: full length

Fonction: CHRAC17 Antibody / POLE3

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human POLE3 protein was used as the immunogen for the CHRAC17 antibody.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal dilution of the CHRAC17 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the CHRAC17 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur POLE3

Antigène: POLE3 (Polymerase (DNA Directed), epsilon 3 (p17 Subunit) (POLE3))

Autre désignation: CHRAC17

Sujet: DNA replication is initiated by the binding of initiation factors to the origin of replication. Nucleosomes inhibit access to the replication machinery at these origin sequences. Nucleosome remodeling factors increase the accessibility of nucleosomal DNA to transcriptional regulators. CHRAC15 and CHRAC17 are subunits of the nucleosomal remodeling factor CHRAC (chromatin accessibility complex), which increases the accessibility of nucleosomal DNA in an ATP-dependent manner. Unlike other known chromatin remodeling factors, CHRAC also functions during chromatin assembly by using ATP to convert irregular chromatin into a regular array of nucleosomes with even spacing. This conversion process occurs when CHRAC organizes randomly deposited histones into a regularly spaced array. In the presence of CHRAC, the nucleosomal ATPase ISWI catalyzes several ATP-dependent transitions of chromatin structure.

UniProt: Q9NRF9

Pathways: Réparation de l'ADN