UBE2C anticorps (full length)

N° du produit ABIN7879294

Cet anticorps anti-UBE2C Monoclonal Souris (Clone CPTC-UBE2C-1) (ABIN7879294) détecte spécifiquement UBE2C dans ELISA et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour UBE2C anticorps (full length) (ABIN7879294)

Antigène: UBE2C (Ubiquitin-Conjugating Enzyme E2C (UBE2C))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp UBE2C est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CPTC-UBE2C-1

Détail du produit anti-UBE2C anticorps

Épitope: full length

Fonction: UBE2C Antibody / UBCH10

Purification: Protein G affinity chromatography

Immunogène: Recombinant human full-length protein was used as the immunogen for the UBE2C antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the UBE2C antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the UBE2C antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur UBE2C

Antigène: UBE2C (Ubiquitin-Conjugating Enzyme E2C (UBE2C))

Autre désignation: UBE2C

Sujet: The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. The first step requires the ATP-dependent activation of the Ub C-terminus and the assembly of multi-Ub chains by the Ub-activating enzyme known as the E1 component. The Ub chain is then conjugated to the Ubconjugating enzyme (E2) to generate an intermediate Ub-E2 complex. The Ub-ligase (E3) then catalyzes the transfer of Ub from E2 to the appropriate protein substrate. UBE2C, also designated UBCH10 in human, is an E2 ubiquitin conjugating enzyme for the anaphase promoting complex (APC), which coordinates mitosis and G1 by sequentially promoting the degradation of key cell-cycle regulators. UBE2C is overexpressed in many different types of cancers and may be a potential therapeutic target.

UniProt: O00762

Pathways: Ubiquitin Proteasome Pathway