Recombinant VASP anticorps (pSer156)

N° du produit ABIN7879711

Cet anticorps anti-VASP Monoclonal Lapin (Clone 32V43) (ABIN7879711) détecte spécifiquement VASP dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant VASP anticorps (pSer156) (ABIN7879711)

Antigène: VASP (Vasodilator-Stimulated phosphoprotein (VASP))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp VASP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 32V43

Détail du produit anti-VASP anticorps

Épitope: pSer156

Fonction: Phospho-VASP (Ser156) Antibody / Vasodilator-stimulated phosphoprotein

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human Phospho-VASP (S156) was used as the immunogen for the Phospho-VASP (Ser156) antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Phospho-VASP (Ser156) antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the Phospho-VASP (Ser156) antibody at -20oC.

Détails sur VASP

Antigène: VASP (Vasodilator-Stimulated phosphoprotein (VASP))

Autre désignation: VASP

Sujet: Phospho-VASP (Ser156) antibody is designed to recognize vasodilator-stimulated phosphoprotein (VASP) when phosphorylated at the serine 156 residue. VASP is a member of the Ena/VASP protein family, which plays a central role in regulating actin cytoskeleton dynamics. This protein localizes to focal adhesions, lamellipodia, and filopodia, where it contributes to actin filament elongation and cell motility. Phosphorylation of VASP at serine 156 by protein kinase A (PKA) or protein kinase G (PKG) reduces its ability to bind actin filaments and modulates cytoskeletal remodeling, thereby influencing cell adhesion and migration.

Phospho-VASP (Ser156) antibody is widely used to study endothelial cell signaling, vascular tone regulation, and platelet activation. VASP phosphorylation is often used as a biomarker for nitric oxide and cGMP-dependent signaling pathways, making this antibody highly relevant for cardiovascular and vascular biology research. In platelets, phosphorylation at serine 156 is associated with inhibition of platelet aggregation, linking this protein to thrombotic and hemostatic processes.

This antibody provides specificity for the phosphorylated serine 156 residue, allowing researchers to distinguish activated signaling states from total VASP levels. It has proven valuable in applications such as western blot, immunohistochemistry, immunofluorescence, and flow cytometry, where phosphorylation-dependent changes in protein activity are key to understanding cellular responses.

Beyond vascular biology, VASP phosphorylation is also studied in cancer research. Altered cytoskeletal regulation contributes to tumor cell invasion and metastasis, and VASP activity is linked to actin-driven protrusions in malignant cells. Monitoring phosphorylation states using phospho-specific antibodies allows scientists to assess signaling cascades that contribute to disease progression.

Phospho-VASP (Ser156) antibody is a reliable reagent for dissecting nitric oxide-mediated signaling and cytoskeletal control. Its specificity for phosphorylation status ensures that researchers can accurately track pathway activation in different cellular contexts. NSJ Bioreagents offers this antibody for investigators focused on cardiovascular biology, oncology, and platelet research.

UniProt: P50552

Pathways: TCR Signaling, Regulation of Actin Filament Polymerization, Tube Formation