Recombinant Acetyl-CoA Carboxylase alpha anticorps

N° du produit ABIN7879860

L’anticorps anti-Acetyl-CoA Carboxylase alpha Monoclonal Lapin est utilisé pour la détection de Acetyl-CoA Carboxylase alpha dans des échantillons de Humain. Il a été validé pour WB, IHC, IF et ICC.

Aperçu rapide pour Recombinant Acetyl-CoA Carboxylase alpha anticorps (ABIN7879860)

Antigène: Acetyl-CoA Carboxylase alpha (ACACA)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Acetyl-CoA Carboxylase alpha est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 32A06

Détail du produit anti-Acetyl-CoA Carboxylase alpha anticorps

Fonction: ACACA Antibody / Acetyl CoA Carboxylase 1

Purification: Affinity chromatography

Immunogène: A synthesized peptide derived from human Acetyl Coenzyme A Carboxylase was used as the immunogen for the ACACA antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the ACACA antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the ACACA antibody at -20oC.

Détails sur Acetyl-CoA Carboxylase alpha

Antigène: Acetyl-CoA Carboxylase alpha (ACACA)

Autre désignation: ACACA

Sujet: ACACA antibody detects Acetyl CoA carboxylase 1, encoded by the ACACA gene. Acetyl CoA carboxylase 1 is a biotin dependent enzyme that catalyzes the conversion of acetyl CoA to malonyl CoA, the rate limiting step of fatty acid biosynthesis. ACACA antibody provides researchers with a specific reagent to study lipid metabolism, metabolic disease, and cancer biology.

Acetyl CoA carboxylase 1 functions by adding a carboxyl group to acetyl CoA, producing malonyl CoA, which serves as the building block for fatty acid elongation. Research using ACACA antibody has demonstrated that this enzyme is highly expressed in lipogenic tissues such as liver and adipose tissue. By controlling malonyl CoA levels, Acetyl CoA carboxylase 1 regulates lipid synthesis and contributes to energy balance.

Studies with ACACA antibody have revealed that Acetyl CoA carboxylase 1 is subject to complex regulation. It is activated by citrate, which reflects nutrient abundance, and inhibited by phosphorylation through AMP activated protein kinase under energy stress conditions. This ensures that fatty acid synthesis occurs only when energy is sufficient. Hormones such as insulin also stimulate Acetyl CoA carboxylase 1 activity, further linking the enzyme to metabolic signaling pathways.

Dysregulation of Acetyl CoA carboxylase 1 has been associated with obesity, diabetes, and cancer. Research using ACACA antibody has shown that elevated activity promotes lipid accumulation and insulin resistance, while inhibition of the enzyme improves metabolic outcomes in animal models. In cancer, increased Acetyl CoA carboxylase 1 expression supports tumor growth by fueling lipid synthesis required for membrane production and signaling. These findings highlight its therapeutic potential in both metabolic and oncologic diseases.

ACACA antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects full length protein and phosphorylated forms, immunohistochemistry demonstrates tissue distribution in metabolic organs, and immunofluorescence shows cytoplasmic localization associated with lipid droplets. These applications make ACACA antibody indispensable for metabolic research.

By supplying validated ACACA antibody reagents, NSJ Bioreagents supports studies into lipid metabolism, metabolic disease, and cancer biology. Detection of Acetyl CoA carboxylase 1 provides insight into how lipid synthesis contributes to physiology and pathology.

UniProt: Q13085

Pathways: AMPK Signaling, Ribonucleoside Biosynthetic Process, L'effet Warburg