ROS1 anticorps

N° du produit ABIN7880120

Cet anticorps Souris Monoclonal détecte spécifiquement ROS1 dans WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour ROS1 anticorps (ABIN7880120)

Antigène: ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase (ROS1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ROS1 est non-conjugé

Application: Western Blotting (WB)

Clone: 1843CT776-78-21

Détail du produit anti-ROS1 anticorps

Fonction: ROS1 Antibody

Purification: Protein G purified

Immunogène: Recombinant human ROS1 was used as the immunogen for the ROS1 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the ROS1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the ROS1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur ROS1

Antigène: ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase (ROS1))

Autre désignation: ROS1

Sujet: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. [UniProt]

UniProt: P08922

Pathways: Signalisation RTK