CUBN anticorps

N° du produit ABIN7880520

L’anticorps anti-CUBN Monoclonal Lapin est utilisé pour la détection de CUBN dans des échantillons de Humain. Il a été validé pour WB et IHC (p).

Aperçu rapide pour CUBN anticorps (ABIN7880520)

Antigène: CUBN (Cubilin (Intrinsic Factor-Cobalamin Receptor) (CUBN))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp CUBN est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: GA-3

Détail du produit anti-CUBN anticorps

Fonction: CUBN Antibody / Cubilin

Purification: Affinity purified

Immunogène: A synthetic peptide specific to human Cubilin / CUBN was used as the immunogen for the CUBN antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the CUBN antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the CUBN antibody at -20oC.

Détails sur CUBN

Antigène: CUBN (Cubilin (Intrinsic Factor-Cobalamin Receptor) (CUBN))

Autre désignation: CUBN

Sujet: Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. [UniProt]

UniProt: O60494

Pathways: Metabolism of Steroid Hormones and Vitamin D, Lipid Metabolism