FURIN anticorps

N° du produit ABIN7880832

L’anticorps anti-FURIN Monoclonal Lapin est utilisé pour la détection de FURIN dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour FURIN anticorps (ABIN7880832)

Antigène: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp FURIN est non-conjugé

Application: Western Blotting (WB)

Clone: AEGA-6

Détail du produit anti-FURIN anticorps

Fonction: Furin Antibody

Purification: Affinity purified

Immunogène: A synthetic peptide specific to human Furin was used as the immunogen for the Furin antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Furin antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the Furin antibody at -20oC.

Détails sur FURIN

Antigène: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Autre désignation: Furin

Sujet: The FURIN gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. [RefSeq]

UniProt: P09958

Pathways: Signalisation Notch, Neurotrophin Signaling Pathway