HSPG2 anticorps

N° du produit ABIN7881008

Cet anticorps Rat Monoclonal détecte spécifiquement HSPG2 dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour HSPG2 anticorps (ABIN7881008)

Antigène: HSPG2 (Heparan Sulfate Proteoglycan 2 (HSPG2))

Reactivité: Humain

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp HSPG2 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: SPM255

Détail du produit anti-HSPG2 anticorps

Fonction: Anti-Perlecan Antibody (HSPG)

Purification: Protein G affinity chromatography

Immunogène: A murine EHS laminin preparation was used as the immunogen for the anti-Perlecan antibody.

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal dilution of the anti-Perlecan antibody should be determined by the researcher.

1. Staining of formalin-fixed tissues requires boiling tissue sections in pH 9 10 mM Tris with 1 mM EDTA for 10-20 min followed by cooling at RT for 20 min
2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide, *For IHC use only*

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the anti-Perlecan antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur HSPG2

Antigène: HSPG2 (Heparan Sulfate Proteoglycan 2 (HSPG2))

Autre désignation: Perlecan

Sujet: This mAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.

UniProt: P98160

Pathways: Glycosaminoglycan Metabolic Process, Lipid Metabolism