INSIG1 anticorps

N° du produit ABIN7881180

L’anticorps anti-INSIG1 Polyclonal Lapin est utilisé pour la détection de INSIG1 dans des échantillons de Souris et Rat. Il a été validé pour WB et FACS.

Aperçu rapide pour INSIG1 anticorps (ABIN7881180)

Antigène: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp INSIG1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Détail du produit anti-INSIG1 anticorps

Fonction: Insig1 Antibody / Insulin-induced gene 1

Séquence: MPRLHDHVWS YPSA

Purification: Affinity purified

Immunogène: Amino acids MPRLHDHVWSYPSA from the rat protein were used as the immunogen for the Insig1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Insig1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Insig1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur INSIG1

Antigène: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Autre désignation: Insig1

Sujet: Insulin induced gene 1, also known as INSIG1, is a protein which in humans is encoded by the INSIG1 gene. This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants.

UniProt: Q08755

Pathways: ER-Nucleus Signaling