IL-3 anticorps

N° du produit ABIN7881306

Cet anticorps Souris Monoclonal détecte spécifiquement IL-3 dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour IL-3 anticorps (ABIN7881306)

Antigène: IL-3 (Interleukin 3 (IL-3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL-3 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: IL3-4001

Détail du produit anti-IL-3 anticorps

Fonction: IL3 Antibody

Purification: Protein A/G affinity

Immunogène: A recombinant protein fragment was used as the immunogen for the IL3 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the IL3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the IL3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur IL-3

Antigène: IL-3 (Interleukin 3 (IL-3))

Autre désignation: IL3

Sujet: Interleukin-3, or IL-3, is a pleiotropic cytokine that is primarily secreted by activated T lymphocytes and stimulates the proliferation and differentiation of hematopoietic cells. IL-3 not only supports growth of both pluripotent stem cells and the more differentiated committed progenitors, but it also stimulates the functional activity of some fully differentiated cells. IL-3 has also been shown to protect mast cells from undergoing apoptosis. IL-3 exerts its biological effects through a receptor which consists of a ligand-specific subunit has been shown to be necessary for activation of the MAP kinase signaling pathway. Although the IL-3 receptor has no intrinsic kinase activity, stimulation with IL-3 leads to tyrosine phosphorylation of the JAK/Tyk 2 family member, JAK2, which in turn activates and causes nuclear translocation of Stat5a and Stat5b.

UniProt: P08700

Pathways: Signalistation JAK/STAT, Regulation of Carbohydrate Metabolic Process, Autophagy