MFGE8 anticorps

N° du produit ABIN7881640

L’anticorps anti-MFGE8 Polyclonal Lapin est utilisé pour la détection de MFGE8 dans des échantillons de Humain. Il a été validé pour WB et IHC (p).

Aperçu rapide pour MFGE8 anticorps (ABIN7881640)

Antigène: MFGE8 (Milk Fat Globule-EGF Factor 8 Protein (MFGE8))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MFGE8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-MFGE8 anticorps

Fonction: MFG-E8 Antibody / Lactadherin / Milk Fat Globule

Séquence: FKVAYSLNGH EFDFIHDVNK KHKE

Purification: Antigen affinity purified

Immunogène: Amino acids FKVAYSLNGHEFDFIHDVNKKHKE from the human protein were used as the immunogen for the MFG-E8 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the MFG-E8 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the MFG-E8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur MFGE8

Antigène: MFGE8 (Milk Fat Globule-EGF Factor 8 Protein (MFGE8))

Autre désignation: MFG-E8

Sujet: MFGE8 (Milk Fat Globule-Egf Factor 8), also called as Lactadherin or SED1, is a protein which in humans is encoded by the MFGE8 gene. Mfge8 is secreted protein found in vertebrates, including mammals as well as birds. By fluorescence in situ hybridization, Collins et al.(1997) mapped the MFGE8 gene to chromosome 15q25. Hanayama et al.(2002) found that MFGE8 is a factor that links apoptotic cells to phagocytes. MFGE8 specifically bound to apoptotic cells by recognizing aminophospholipids such as phosphatidylserine. MFGE8, when engaged by phospholipids, bound to cells via its RGD motif. It bound particularly strongly to cells expressing alpha-V-beta-3 integrin. Bu et al.(2007) showed that Mfge8 was expressed in intestinal lamina propria macrophages in mice. Using a wound-healing assay, they showed that Mfge8 promoted migration of intestinal epithelial cells through a PKC-epsilon(PRKCE)-dependent mechanism.

UniProt: Q08431

Pathways: SARS-CoV-2 Protein Interactome