Recombinant MAPKAP Kinase 3 anticorps

N° du produit ABIN7881657

Cet anticorps Lapin Monoclonal détecte spécifiquement MAPKAP Kinase 3 dans WB et IP. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant MAPKAP Kinase 3 anticorps (ABIN7881657)

Antigène: MAPKAP Kinase 3 (MAPKAPK3) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 (MAPKAPK3))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp MAPKAP Kinase 3 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Clone: 30M15

Détail du produit anti-MAPKAP Kinase 3 anticorps

Fonction: MAPKAPK3 Antibody / Mitogen activated protein kinase activated protein kinase 3

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human MK3 was used as the immunogen for the MAPKAPK3 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the MAPKAPK3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the MAPKAPK3 antibody at -20oC.

Détails sur MAPKAP Kinase 3

Antigène: MAPKAP Kinase 3 (MAPKAPK3) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 (MAPKAPK3))

Autre désignation: MAPKAPK3

Sujet: MAPKAPK3 antibody recognizes Mitogen activated protein kinase activated protein kinase 3, encoded by the MAPKAPK3 gene. This protein is a serine threonine kinase activated downstream of p38 MAP kinase and is part of a signaling cascade that regulates stress responses, transcription, and cytoskeletal organization. MAPKAPK3 antibody provides researchers with a powerful tool to study how external stimuli such as cytokines, heat shock, or ultraviolet radiation trigger intracellular signaling events that lead to adaptive changes in cell physiology. By detecting MAPKAPK3, scientists can better understand how stress activated kinases contribute to survival, inflammation, and differentiation.

Mitogen activated protein kinase activated protein kinase 3 phosphorylates a variety of substrates, including transcription factors, RNA binding proteins, and regulators of actin dynamics. This allows MAPKAPK3 to integrate stress signals with gene expression programs and structural remodeling. Studies with MAPKAPK3 antibody have shown that it participates in the regulation of CREB and ATF1 transcription factors, influencing expression of stress inducible genes. It also phosphorylates the small heat shock protein HSP27, altering cytoskeletal dynamics and cell motility. These diverse downstream targets highlight the broad influence of MAPKAPK3 in cellular adaptation.

Dysregulation of MAPKAPK3 signaling has been implicated in inflammation, cancer, and neurological disorders. Overactivation of p38 MAPK and its downstream kinases contributes to chronic inflammatory states and has been studied in conditions such as rheumatoid arthritis and inflammatory bowel disease. Research with MAPKAPK3 antibody has revealed that altered MAPKAPK3 activity can promote tumorigenesis by enhancing survival pathways and stress resistance in cancer cells. In the nervous system, MAPKAPK3 has been implicated in synaptic plasticity and memory, suggesting that disruption of its activity may contribute to cognitive impairment and neurodegeneration.

MAPKAPK3 antibody is widely applied in western blotting, immunohistochemistry, and kinase assays. Western blotting detects activation and phosphorylation states, while immunohistochemistry reveals tissue specific expression patterns. Kinase assays using immunoprecipitated MAPKAPK3 protein help identify novel substrates and confirm functional activity. These approaches allow comprehensive characterization of MAPKAPK3 signaling in both health and disease.

By providing validated MAPKAPK3 antibody reagents, NSJ Bioreagents supports research into stress activated kinase pathways, offering tools to dissect how extracellular cues are transduced into cellular outcomes. Understanding the role of Mitogen activated protein kinase activated protein kinase 3 will continue to provide insights into therapeutic approaches for inflammatory disease, cancer, and neurological disorders.

UniProt: Q16644

Pathways: Signalisation MAPK, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades