MBP anticorps

N° du produit ABIN7881703

L’anticorps anti-MBP Monoclonal Rat est utilisé pour la détection de MBP dans des échantillons de Humain. Il a été validé pour WB et IHC (p).

Aperçu rapide pour MBP anticorps (ABIN7881703)

Antigène: MBP (Myelin Basic Protein (MBP))

Reactivité: Humain

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp MBP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: MBP-4274

Détail du produit anti-MBP anticorps

Fonction: Myelin Basic Protein Antibody (azide and preservative free)

Séquence: GILDSIGRFF GGDRG

Purification: Protein G affinity chromatography

Immunogène: Amino acids GILDSIGRFFGGDRG from the human protein were used as the immunogen for the Myelin Basic Protein antibody.

Isotype: IgG2b

Information d'application

Indications d'application: Optimal dilution of the Myelin Basic Protein antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Myelin Basic Protein antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur MBP

Antigène: MBP (Myelin Basic Protein (MBP))

Autre désignation: Myelin Basic Protein

Sujet: Myelin basic protein (MBP) is the second most abundant protein in central nervous system (CNS) myelin: it comprises 30 % of the total protein and about 10 % of the dry weight of myelin. It is the only structural protein found so far to be essential for formation of CNS myelin, and has been called the executive molecule of myelin . MBP can interact with a number of polyanionic proteins including actin, tubulin, calmodulin, and clathrin, and negatively charged lipids, and acquires structure on binding to them. It may act as a membrane actin-binding protein, which might allow it to participate in transmission of extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin. MBP may be applicable as a marker for oligodendrogliomas. MBP/4274 recognizes an epitope in the 36-50 region of MBP, useful in clinical diagnosis to detect MBP levels or myelination in human MBP.

UniProt: P02686