PERK anticorps (pThr980)

N° du produit ABIN744713

L’anticorps Lapin Polyclonal anti-PERK a été validé pour WB, ELISA, IHC (p), FACS, IF (cc), IF (p) et IHC (fro). Il convient pour détecter PERK dans des échantillons de Humain, Souris, Rat, Chien et Porc. Il y a 14+ publications disponibles.

Aperçu rapide pour PERK anticorps (pThr980) (ABIN744713)

Antigène: PERK (EIF2AK3) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))

Reactivité: Humain, Souris, Rat, Chien, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PERK est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-PERK anticorps

Épitope: pThr980

Réactivité croisée: Chien, Humain, Souris, Porc, Rat

Homologie: Cow,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from mouse PERK around the phosphorylation site of Thr980

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-PERK (ABIN744713)

Kao, Lai, Chow, Liao, Zheng, Tsai, Hsia, Lai, Lee, Chuang, Whang-Peng, Yao: "Opposite Regulation of CHOP and GRP78 and Synergistic Apoptosis Induction by Selenium Yeast and Fish Oil via AMPK Activation in Lung Adenocarcinoma Cells." dans: Nutrients, Vol. 10, Issue 10, (2019) (PubMed).

Ju, Su, Chen, Ma, Ji, Wang, Li, Li: "Protective effects of Astragaloside IV on endoplasmic reticulum stress-induced renal tubular epithelial cells apoptosis in type 2 diabetic nephropathy rats." dans: Biomedicine & pharmacotherapy, Vol. 109, pp. 84-92, (2019) (PubMed).

Gerbino, Bottillo, Milano, Lipari, Zio, Morlino, Mola, Procino, Re, Zachara, Grammatico, Svelto, Carmosino: "Functional Characterization of a Novel Truncating Mutation in Lamin A/C Gene in a Family with a Severe Cardiomyopathy with Conduction Defects." dans: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 44, Issue 4, pp. 1559-1577, (2018) (PubMed).

Fang, Liu, Wu, Liu, Pan, Li: "Upregulation of long noncoding RNA CCAT1-L promotes epithelial-mesenchymal transition in gastric adenocarcinoma." dans: OncoTargets and therapy, Vol. 11, pp. 5647-5655, (2018) (PubMed).

Fang, Yan, Teng, Wen, Li, Peng, Liu, Donadeu, Zhao, Hua: "Melatonin prevents senescence of canine adipose-derived mesenchymal stem cells through activating NRF2 and inhibiting ER stress." dans: Aging, Vol. 10, Issue 10, pp. 2954-2972, (2018) (PubMed).

Mak, Yu, Sun, He, Liu, Yang: "Tetramethylpyrazine suppresses angiotensin II-induced soluble epoxide hydrolase expression in coronary endothelium via anti-ER stress mechanism." dans: Toxicology and applied pharmacology, Vol. 336, pp. 84-93, (2017) (PubMed).

Chen, Holstein, Aime, Bollo, Lechleiter: "Calcineurin β protects brain after injury by activating the unfolded protein response." dans: Neurobiology of disease, Vol. 94, pp. 139-56, (2016) (PubMed).

Carmosino, Gerbino, Schena, Procino, Miglionico, Forleo, Favale, Svelto: "The expression of Lamin A mutant R321X leads to endoplasmic reticulum stress with aberrant Ca(2+) handling." dans: Journal of cellular and molecular medicine, Vol. 20, Issue 11, pp. 2194-2207, (2016) (PubMed).

Yu, Zhang, Zhao, Guo, Li, Li, Zhang, Sun: "Gypenoside Protects against Myocardial Ischemia-Reperfusion Injury by Inhibiting Cardiomyocytes Apoptosis via Inhibition of CHOP Pathway and Activation of PI3K/Akt Pathway In Vivo and In Vitro." dans: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 39, Issue 1, pp. 123-36, (2016) (PubMed).

Santanam, Banach-Petrosky, Abate-Shen, Shen, White, DiPaola: "Atg7 cooperates with Pten loss to drive prostate cancer tumor growth." dans: Genes & development, Vol. 30, Issue 4, pp. 399-407, (2016) (PubMed).

Xu, Su, Song, Shi, Fu, Hu, Xia, Song, Song: "Polychlorinated biphenyl quinone induces endoplasmic reticulum stress, unfolded protein response, and calcium release." dans: Chemical research in toxicology, Vol. 28, Issue 6, pp. 1326-37, (2015) (PubMed).

He, Long, Zhong, Fu, Li, Lin: "Sustained endoplasmic reticulum stress inhibits hepatocyte proliferation via downregulation of c-Met expression." dans: Molecular and cellular biochemistry, Vol. 389, Issue 1-2, pp. 151-8, (2014) (PubMed).

Kucuksayan, Konuk, Demir, Mutus, Aslan: "Neutral sphingomyelinase inhibition decreases ER stress-mediated apoptosis and inducible nitric oxide synthase in retinal pigment epithelial cells." dans: Free radical biology & medicine, Vol. 72, pp. 113-23, (2014) (PubMed).

Aslan, Basaranlar, Unal, Ciftcioglu, Derin, Mutus: "Inhibition of neutral sphingomyelinase decreases elevated levels of inducible nitric oxide synthase and apoptotic cell death in ocular hypertensive rats." dans: Toxicology and applied pharmacology, (2014) (PubMed).

Détails sur PERK

Antigène: PERK (EIF2AK3) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))

Autre désignation: PERK

Sujet:

Synonyms: Pek, Perk, AI427929, Eukaryotic translation initiation factor 2-alpha kinase 3, PRKR-like endoplasmic reticulum kinase, Pancreatic eIF2-alpha kinase, Eif2ak3

Background: Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.

ID gène: 13666

UniProt: Q9Z2B5

Pathways: Hormone Transport, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response