ADRA2A anticorps (Extracellular, N-Term)

N° du produit ABIN7884749

Cet anticorps anti-ADRA2A Polyclonal Lapin (ABIN7884749) détecte spécifiquement ADRA2A dans WB, IF, IHC et FACS. L’anticorps est réactif avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour ADRA2A anticorps (Extracellular, N-Term) (ABIN7884749)

Antigène: ADRA2A (Alpha-2A Adrenergic Receptor (ADRA2A))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ADRA2A est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Classe de qualité: Carrier-free

Détail du produit anti-ADRA2A anticorps

Épitope: AA 7-20, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to α2A-Adrenergic Receptor

Homologie: Mouse - identical, human - 13,14 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)DAGNSSWNGTEAPG, corresponding to amino acid residues 7-20 of rat alpha2A-adrenoceptor

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:250

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7234696)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur ADRA2A

Antigène: ADRA2A (Alpha-2A Adrenergic Receptor (ADRA2A))

Autre désignation: Alpha-2A adrenoceptor

Sujet:

Synonyms: Alpha-2A adrenoceptor, Alpha-2D adrenergic Receptor, α-2AAR, ADA2A, ADRA2A

Description: Adrenergic receptors (also called adrenoceptors) are the receptors for the catecholamines adrenaline and noradrenaline (called epinephrine and norepinephrine in the United States). Adrenaline and noradrenaline play important roles in the control of blood pressure, myocardial contractile rate and force, airway reactivity, and a variety of metabolic and central nervous system functions. Adrenergic receptors are members of the G-protein coupled receptor (GPCR) superfamily of membrane proteins. They share a common structure of seven putative transmembrane domains, an extracellular N-terminus, and a cytoplasmic C- terminus.Adrenoceptors are divided into three types: α1, α2 and β-adrenoceptors. Each type is further divided into at least three subtypes: α1A, α1B, α1D, α2A, α2B, α2C, β1, β2, β31,2. Adrenoceptors are expressed in nearly all peripheral tissues and in the central nervous system1,2. In general, the pharmacological properties of each subtype are quite homogenous across different species. However, this is not the case for the α2A subtype which was first isolated from human platelets3. This subtype shows different pharmacological properties from that of mouse and rat. For this reason, until molecular techniques significantly advanced, it was believed that human α2A and that of mouse and rat (termed α2D) were two different subtypes. Today, it is accepted that these two subtypes are in fact one gene product and is generally termed α2A. One of the main differences between this subtype from the different organisms is its affinity for yohimbine and rauwolscine, rat and mouse α2A displays less affinity compared to human3,4.

ID gène: 25083

UniProt: P22909

Pathways: EGFR Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Negative Regulation of Transporter Activity