Cortactin anticorps (Intracellular)

N° du produit ABIN7884899

Cet anticorps anti-Cortactin Polyclonal Lapin (ABIN7884899) détecte spécifiquement Cortactin dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Cortactin anticorps (Intracellular) (ABIN7884899)

Antigène: Cortactin (CTTN)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cortactin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Classe de qualité: Carrier-free

Détail du produit anti-Cortactin anticorps

Épitope: AA 346-359, Intracellular

Fonction: A Rabbit Polyclonal Antibody to Cortactin

Homologie: Rat,human - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)KTSNIRANFENLAK, corresponding to amino acid residues 346 - 359 of mouse Cortactin

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200-1:1000

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235169)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Cortactin

Antigène: Cortactin (CTTN)

Autre désignation: Src substrate cortactin

Sujet:

Synonyms: Src substrate cortactin, Oncogene EMS1, EMS1, Amplaxin, CTTN

Description: Cortical acting binding protein, Cortactin, is an actin-binding protein involved in cytoskeletal regulation1. Cortactin is a 63-65 kDa protein that consists of four major domains: N-terminal acidic (NTA), 6.5 tandems repeat, proline-rich domain, and the C-terminal Src homology 3 domains (SH3 domains)2 and it is regulated by post translational modifications such as phosphorylation and acetylation1.The actin filament network provides mechanical support as well as protrusive and contractile forces essential for directed cell motility and cell and tissue morphogenesis. Cortactin activates the Arp2/3 complex, the main regulator of actin polymerization, and thereby regulates the assembly of branched actin3.Overexpression of cortactin was shown to enhance cell migration, invasion, and tumor cell metastasis. It is also overexpressed in various types of cancer such as breast cancers as well as head and neck tumors1.

ID gène: 13043

UniProt: Q60598

Pathways: Signalisation MAPK