Dopamine d2 Receptor anticorps (Extracellular, N-Term)

N° du produit ABIN7884918

Cet anticorps Lapin Polyclonal détecte spécifiquement Dopamine d2 Receptor dans WB, IHC, FACS et LCI. Il présente une réactivité avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour Dopamine d2 Receptor anticorps (Extracellular, N-Term) (ABIN7884918)

Antigène: Dopamine d2 Receptor (DRD2) (Dopamine Receptor D2 (DRD2))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Dopamine d2 Receptor est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-Dopamine d2 Receptor anticorps

Épitope: AA 11-26, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to D2 Dopamine Receptor

Homologie: Mouse - identical, human - 15,16 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)DDLERQNWSRPFNGSE, corresponding to amino acid residues 11-26 of rat DRD2 

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235239)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Dopamine d2 Receptor

Antigène: Dopamine d2 Receptor (DRD2) (Dopamine Receptor D2 (DRD2))

Autre désignation: DRD2

Sujet:

Synonyms: DRD2, D(2) dopamine receptor

Description: The D2 dopamine receptor (DRD2) is one of five receptors that mediate the effects of the catecholamine neurotransmitter dopamine. Dopamine regulates a variety of functions including locomotor activity, emotion, positive reinforcement, food intake, and endocrine regulation. The dopaminergic system has been extensively studied in the last thirty years mainly because its dysregulation has been linked to several neurological and neuropsychiatric diseases including Parkinson's disease and schizophrenia.1All five dopamine receptors belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.Historically, the five receptors have been divided into two subfamilies based on pharmacological and structural considerations: the D1-like subfamily (that includes the D1 and D5 subtypes) and the D2-like subfamily (that includes the D2-, D3- and D4 subtypes).1The D1-like receptors are coupled to Gs-type G proteins and enhance adenylate cyclase activity while the D2-like receptors are coupled to Gi-type G proteins and inhibit adenylate cyclase activity.1D2 receptor expression in the brain is largely confined to the striatum, prefrontal cortex and hypothalamus.1Dysregulation of D2 receptor function has been implicated in several disorders including schizophrenia, bipolar disorder, Parkinson's disease, and restless legs syndrome. Consistent with this, treatments that either block or activate the D2 receptor have been developed to treat these diseases.2

ID gène: 24318

UniProt: P61169

Pathways: Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Inositol Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Feeding Behaviour, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity