Glucagon Receptor anticorps (1st Extracellular Loop)

N° du produit ABIN7885043

Cet anticorps anti-Glucagon Receptor Polyclonal Lapin (ABIN7885043) détecte spécifiquement Glucagon Receptor dans WB, IHC et IF. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Glucagon Receptor anticorps (1st Extracellular Loop) (ABIN7885043)

Antigène: Glucagon Receptor (GCGR)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Glucagon Receptor est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Classe de qualité: Carrier-free

Détail du produit anti-Glucagon Receptor anticorps

Épitope: 1st Extracellular Loop, AA 200-212

Fonction: A Rabbit Polyclonal Antibody to Glucagon Receptor

Homologie: Mouse - identical, human - 12,13 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)KTRYSQKIGDDLS, corresponding to amino acid residues 200-212 of rat GCGR

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235603)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Glucagon Receptor

Antigène: Glucagon Receptor (GCGR)

Autre désignation: GCGR

Sujet:

Synonyms: GCGR, GLR

Description: The glucagon receptor (GCGR) is one of the 15 members of the secretin-like (class B) family of G-protein-coupled receptors (GPCRs) in humans. Glucagon is a highly conserved 29 amino acid protein processed from proglucagon by PC2 in pancreatic α-cells. The principal actions of glucagon involve regulation of metabolic pathways involved in glucose homeostasis1. Glucagon binding to the GCGR activates adenylyl cyclase through heterotrimeric Gs G proteins, leading to an increase in intracellular cAMP levels and subsequent activation of PKA signaling2. The glucagon receptor is a 485-amino acid protein with a central core consisting of seven membrane-spanning domains, an extracellular N-terminus and a cytoplasmic C-terminal tail2.Glucagon receptors are widely expressed in multiple tissues including the liver, brain, pancreas, heart, kidney, and smooth muscle cell in the gastrointestinal tract and peripheral vasculature1.Abnormal glucagon signaling is associated with hyperglycemia in patients with type 2 diabetes3. Mice with homozygous null mutation of GCGR exhibit chronic hypoglycemia, extreme hyperglucagonemia, and α cell hyperplasia4. GCGR is a potential drug target for type 2 diabetes5.

ID gène: 24953

UniProt: P30082

Pathways: Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process