Prokineticin Receptor 2 anticorps (Extracellular, N-Term)

N° du produit ABIN7885322

Cet anticorps anti-Prokineticin Receptor 2 Polyclonal Lapin (ABIN7885322) détecte spécifiquement Prokineticin Receptor 2 dans WB, IHC, FACS, IF et LCI. L’anticorps est réactif avec des échantillons de Souris et Rat.

Aperçu rapide pour Prokineticin Receptor 2 anticorps (Extracellular, N-Term) (ABIN7885322)

Antigène: Prokineticin Receptor 2 (PROKR2)

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Prokineticin Receptor 2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free, KO Validated

Détail du produit anti-Prokineticin Receptor 2 anticorps

Épitope: AA 3-15, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to Prokineticin Receptor 2

Homologie: Mouse - 11,13 amino acid residues identical, human - 9

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)DQNGNTSFAPDLN, corresponding to amino acid residues 3-15 of rat PROKR2

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:100

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236613)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Prokineticin Receptor 2

Antigène: Prokineticin Receptor 2 (PROKR2)

Autre désignation: PROKR2

Sujet:

Synonyms: PROKR2, PKR2, G-protein coupled receptor 73-like 1, Gpr73l1, Gpr73b, G-protein coupled receptor I5E

Description: The Prokineticins (PK1 and PK2) are a pair of cysteine-rich secreted peptides with broad physiological functions including gastrointestinal motility, angiogenesis, hematopoiesis and circadian rhythms regulation.The biological effects of PK1 and PK2 are mediated by two highly homologous receptors termed Prokineticin receptor 1 (PKR1) and Prokineticin receptor 2 (PKR2) that belong to the 7-transmembrane domain, G-protein coupled receptor (GPCR) superfamily. Both PK ligands activate the two PK receptors with similar potency.1PKR2 receptors couple to Gq/G11 proteins leading to phospholipase C activation, inositol phosphate production and calcium mobilization.The distribution of PKR2 is relatively restricted with high expression levels in the brain, spinal cord and dorsal root ganglions, in organs of the reproductive system and in endocrine tissues such as the thyroid, pituitary and adrenal glands.1The PK2 ligand has been shown to be involved in the regulation of circadian rhythms of physiological and behavioral processes in mammals, probably through signaling via PKR2 which is highly expressed in the suprachiasmatic nucleus (SCN), an area of the brain that controls circadian rhythm processes.2In addition, loss-of-function mutations in the PKR2 gene have been associated with Kallmann Syndrome, a condition characterized by idiopathic hypogonadotropic hypogonadism (IHH) in combination with anosmia, a compromised sense of smell.3

ID gène: 192649

UniProt: Q8R415

Pathways: Signalisation Hedgehog, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma