Sortilin 1 anticorps (Extracellular Domain)

N° du produit ABIN7885532

Cet anticorps anti-Sortilin 1 Polyclonal Lapin (ABIN7885532) détecte spécifiquement Sortilin 1 dans WB, IHC, FACS, IF et LCI. L’anticorps est réactif avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour Sortilin 1 anticorps (Extracellular Domain) (ABIN7885532)

Antigène: Sortilin 1 (SORT1)

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Sortilin 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free, KO Validated

Détail du produit anti-Sortilin 1 anticorps

Épitope: AA 320-335, Extracellular Domain

Fonction: A Rabbit Polyclonal Antibody to Sortilin

Homologie: Mouse,rat - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: DKDTTRRIHVSTDQD(C) corresponding to amino acid residues 320-335 of human Sortilin

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:400

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7237255)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Sortilin 1

Antigène: Sortilin 1 (SORT1)

Autre désignation: SORT1

Sujet:

Synonyms: SORT1, Neurotensin receptor 3, NTR3, NT3, Glycoprotein 95, Gp95

Description: Sortilin is a member of the Vps10p family named for a yeast gene that is involved in trafficking between the trans-golgi network and the vacuole. In mammals sortilin has been shown to play an important role in golgi to endosome and golgi to lysosome trafficking. Sortilin is also known as neurotensin receptor 3 (NTS3), one of the receptors for the peptide neurotransmitter neurotensin that exerts several biological functions ranging from the regulation of dopamine transmission and pain in the central nervous system to its functioning as a local hormone affecting the gastrointestinal tract. In addition, sortilin has lately been identified as a co-receptor of p75NTR for the binding of the proneurotrophins proNGF and proBDNF. Moreover, sortilin expression was found to be essential for proNGF and proBDNF-induced neuronal cell death.Sortilin is a type I membrane protein with a large extracellular domain that includes 8 bacterial neuraminidase repeats (BNRs), a single transmembrane region and a short cytoplasmic tail. The protein is expressed in several tissues, most notably in the brain, spinal cord, skeletal muscle and adipocytes.Paradoxically for its role as either a neurotensin receptor or a p75NTR co-receptor for proneurotrophins, about 90 % of sortilin is retained in intracellular compartments with only about 10 % reaching the cell surface. It has been speculated, that changes in the cellular environment may increase cell surface expression of sortilin.

ID gène: 6272

UniProt: Q99523

Pathways: Neurotrophin Signaling Pathway