HIRA anticorps

N° du produit ABIN7938156

Cet anticorps anti-HIRA Monoclonal Souris (Clone WC119-2H11) (ABIN7938156) détecte spécifiquement HIRA dans WB, IF et ICC. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour HIRA anticorps (ABIN7938156)

Antigène: HIRA (HIR Histone Cell Cycle Regulation Defective Homolog A (HIRA))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HIRA est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: WC119-2H11

Détail du produit anti-HIRA anticorps

Fonction: HIRA antibody (mAb) (Clone WC119.2H11)

Purification: Protein G Chromatography

Immunogène: This HIRA antibody was raised against a GST-fusion protein containing residues 421-729 of human HIRA.

Isotype: IgG

Information d'application

Indications d'application: WB: 1 - 2 μg/mL dilution For optimal results, we recommend the addition of 0.05 % Tween-20 to all blocking solutions to reduce background in Western blot.

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Stock: -20 °C

Stockage commentaire: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Date de péremption: 24 months

Détails sur HIRA

Antigène: HIRA (HIR Histone Cell Cycle Regulation Defective Homolog A (HIRA))

Autre désignation: HIRA

Sujet:

Background_Plain: HIRA (DGCR1, TUP1) is a histone chaperone that preferentially places the variant Histone H3.3 in nucleosomes, replacing canonical Histone H3 during the cell cycle. HIRA is required for the periodic repression of histone gene transcription during the cell cycle and when complexed with ASF1a is involved in the formation of the senescence-associated heterochromatin foci.

Aliases: TUP1, DGCR1, TUPLE1

Poids moléculaire: 120 kDa

NCBI Accession: NP_003316

Pathways: Chromatin Binding