Recombinant UBE2S anticorps

N° du produit ABIN7938534

Cet anticorps anti-UBE2S Monoclonal Lapin (Clone 6D18) (ABIN7938534) détecte spécifiquement UBE2S dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour Recombinant UBE2S anticorps (ABIN7938534)

Antigène: UBE2S (Ubiquitin-Conjugating Enzyme E2S (UBE2S))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp UBE2S est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 6D18

Détail du produit anti-UBE2S anticorps

Fonction: UBE2S antibody (rAb), 100 μg (Clone 6D18)

Purification: Protein A Chromatography

Immunogène: This antibody was raised against the UBE2S fusion protein.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:5000-1:50000 dilution IHC: 1:2000-1:10000 dilution

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in PBS, pH 7.3, with 50 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Stock: -20 °C

Stockage commentaire: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Date de péremption: 24 months

Détails sur UBE2S

Antigène: UBE2S (Ubiquitin-Conjugating Enzyme E2S (UBE2S))

Autre désignation: UBE2S

Sujet:

Background_Plain: UBE2S (Ubiquitin-conjugating enzyme E2 S) also known as E2-EPF, E2EPF and EPF5. UBE2S is a member of the E2 ubiquitin-conjugating enzyme family which is required for post-replicative DNA damage repair and plays an important role in various cellular processes. UBE2S can accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro, it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination.

Aliases: Ubiquitin conjugating enzyme E2 S, E2-EPF, E2EPF, EPF5

Poids moléculaire: 24 kDa

Pathways: Ubiquitin Proteasome Pathway