HAAO anticorps (AA 52-286) (HRP)

N° du produit ABIN7964895

Cet anticorps anti-HAAO Polyclonal Lapin conjugué à HRP (ABIN7964895) détecte spécifiquement HAAO dans WB, ELISA et IHC. L’anticorps est réactif avec des échantillons de Humain et Rat.

Aperçu rapide pour HAAO anticorps (AA 52-286) (HRP) (ABIN7964895)

Antigène: HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HAAO est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-HAAO anticorps (HRP)

Épitope: AA 52-286

Fonction: Anti-HAAO Antibody HRP Conjugated

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Human HAAO shares 86.3%,88.5% amino acid (aa) sequence identity with mouse,rat HAAO,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human HAAO recombinant protein (Position: E52-G286). Human HAAO shares 86.3% and 88.5% amino acid (aa) sequence identity with mouse and rat HAAO, respectively.

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur HAAO

Antigène: HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))

Autre désignation: HAAO

Sujet:

Background: 3-hydroxyanthranilate 3,4-dioxygenase (EC 1.13.11.6) is an enzyme encoded by the HAAO gene. 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.

Gene Full Name: 3-hydroxyanthranilate 3,4-dioxygenase

ID gène: 23498

UniProt: P46952