Adenosine A2a Receptor anticorps (AA 144-410) (PE)

N° du produit ABIN7966614

Cet anticorps anti-Adenosine A2a Receptor Polyclonal Lapin conjugué à PE (ABIN7966614) détecte spécifiquement Adenosine A2a Receptor dans FACS. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour Adenosine A2a Receptor anticorps (AA 144-410) (PE) (ABIN7966614)

Antigène: Adenosine A2a Receptor (ADORA2A)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Adenosine A2a Receptor est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Détail du produit anti-Adenosine A2a Receptor anticorps (PE)

Épitope: AA 144-410

Fonction: Anti-ADORA2A Antibody PE Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human ADORA2A shares 76.8%,75.3% amino acid (aa) sequence identity with mouse,rat ADORA2A,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human ADORA2A recombinant protein (Position: N144-G410). Human ADORA2A shares 76.8% and 75.3% amino acid (aa) sequence identity with mouse and rat ADORA2A, respectively.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur Adenosine A2a Receptor

Antigène: Adenosine A2a Receptor (ADORA2A)

Autre désignation: ADORA2A

Sujet:

Background: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding.

Gene Full Name: adenosine A2a receptor

ID gène: 135

UniProt: P29274

Pathways: Neurotrophin Signaling Pathway, cAMP Metabolic Process, Synaptic Membrane, Feeding Behaviour, Cancer Immune Checkpoints