Angiopoietin 2 anticorps (AA 19-348) (Fluoro550)

N° du produit ABIN7968490

Cet anticorps Lapin Polyclonal détecte spécifiquement Angiopoietin 2 dans FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Angiopoietin 2 anticorps (AA 19-348) (Fluoro550) (ABIN7968490)

Antigène: Angiopoietin 2 (ANGPT2)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Angiopoietin 2 est conjugé à/à la Fluoro550

Application: Flow Cytometry (FACS)

Détail du produit anti-Angiopoietin 2 anticorps (Fluoro550)

Épitope: AA 19-348

Fonction: Anti-Angiopoietin 2/ANGPT2 Antibody Fluoro550 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human Angiopoietin 2 shares 84%,85% amino acid (aa) sequences identity with mouse,rat Angiopoietin 2,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Angiopoietin 2 recombinant protein (Position: Y19-N348). Human Angiopoietin 2 shares 84% and 85% amino acid (aa) sequences identity with mouse and rat Angiopoietin 2, respectively.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur Angiopoietin 2

Antigène: Angiopoietin 2 (ANGPT2)

Autre désignation: ANGPT2

Sujet:

Background: ANGPT2, also known as ANG2 or Angiopoietin 2, is a protein that in humans is encoded by the ANGPT2 gene. It is mapped to 8p23.1. ANGPT2 is a naturally occurring antagonist of ANG1 that competes for binding to the TIE2 receptor and blocks ANGPT1-induced TIE2 autophosphorylation during vasculogenesis. The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. ANGPT2 was significantly increased in plasma and alveolar edema fluid in adults with acute lung injury compared to controls or patients with hydrostatic pulmonary edema, tracheal. ANGPT2 was also significantly increased in neonates with respiratory distress syndrome who developed bronchopulmonary edema. It is also a mediator of epithelial necrosis with an important role in hyperoxic acute lung injury and pulmonary edema.

Gene Full Name: angiopoietin 2

Sequence Similarities: Contains 1 fibrinogen C-terminal domain.

ID gène: 285

UniProt: O15123

Pathways: Signalisation RTK