Aspartate beta Hydroxylase anticorps (C-Term) (Fluoro488)

N° du produit ABIN7970392

L’anticorps anti-Aspartate beta Hydroxylase Polyclonal Lapin est utilisé pour la détection de Aspartate beta Hydroxylase dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour Aspartate beta Hydroxylase anticorps (C-Term) (Fluoro488) (ABIN7970392)

Antigène: Aspartate beta Hydroxylase (ASPH) (Aspartate beta-Hydroxylase (ASPH))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Aspartate beta Hydroxylase est conjugé à/à la Fluoro488

Application: Flow Cytometry (FACS)

Détail du produit anti-Aspartate beta Hydroxylase anticorps (Fluoro488)

Épitope: C-Term

Fonction: Anti-Aspartate beta hydroxylase/ASPH Antibody Fluoro488 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: identical to the related mouse sequence.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human ASPH, identical to the related mouse sequence.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur Aspartate beta Hydroxylase

Antigène: Aspartate beta Hydroxylase (ASPH) (Aspartate beta-Hydroxylase (ASPH))

Autre désignation: ASPH

Sujet:

Background: ASPH is also known as Aspartyl/asparaginyl beta-hydroxylase. This gene is thought to play an important role in calcium homeostasis. And the gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis.

Gene Full Name: aspartate beta-hydroxylase

Sequence Similarities: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.

ID gène: 444

UniProt: Q12797

Pathways: Positive Regulation of Endopeptidase Activity