PAK4 anticorps (AA 501-591) (Biotin)

N° du produit ABIN747520

Cet anticorps Lapin Polyclonal détecte spécifiquement PAK4 dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour PAK4 anticorps (AA 501-591) (Biotin) (ABIN747520)

Antigène: PAK4 (P21-Activated Kinase 4 (PAK4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAK4 est conjugé à/à la Biotin

Application: Western Blotting (WB)

Détail du produit anti-PAK4 anticorps (Biotin)

Épitope: AA 501-591

Homologie: Human,Mouse,Rat,Dog,Cow,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human PAK4

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur PAK4

Antigène: PAK4 (P21-Activated Kinase 4 (PAK4))

Autre désignation: PAK4

Sujet:

Synonyms: p21 activated kinase 4, p21CDKN1A activated kinase 4, PAK 4, Protein kinase related to S.cerevisiae STE20 effector for Cdc42Hs, Serine threonine kinase PAK 4, Serine/threonine protein kinase PAK 4, Serine/threonine protein kinase PAK4, KIAA1142, PAK4_HUMAN.

Background: p21-activated kinases (PAKs) belong to the family of serine/threonine kinases involved in the control of various cellular processes, including the cell cycle, dynamics of the cytoskeleton, apoptosis, oncogenic transformation, and transcription. All PAK family members are characterized by the presence of p21-binding domain. p21-activated kinases are regulated by the small GTP-binding proteins Rac and Cdc42, and lipids, which stimulate autophosphorylation and phosphorylation of exogenous substrates. Serine (Ser-474) is the likely autophosphorylation site in the kinase domain of PAK4 in vivo. Phosphospecific directed against serine 474 detect activated PAK4 on the Golgi membrane when PAK4 is co-expressed with activated Cdc42. Current data strongly implicates PAK-4 in oncogenesis. PAK4 is frequently overexpressed in human tumor cell lines of various tissue origins.

ID gène: 10298

Pathways: Signalisation RTK