CISH anticorps (C-Term) (FITC)

N° du produit ABIN7983535

L’anticorps anti-CISH Polyclonal Lapin est utilisé pour la détection de CISH dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour CISH anticorps (C-Term) (FITC) (ABIN7983535)

Antigène: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CISH est conjugé à/à la FITC

Application: Flow Cytometry (FACS)

Détail du produit anti-CISH anticorps (FITC)

Épitope: C-Term

Fonction: Anti-CISH Antibody FITC Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: identical to the related rat,mouse sequences.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human CISH, identical to the related rat and mouse sequences.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur CISH

Antigène: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Autre désignation: CISH

Sujet:

Background: CISH (cytokine inducible SH2-containing protein),also called CIS, CIS-1, G18, SOCS, is an important negative regulator for inflammatory signaling and belongs to the suppressors of cytokine signaling (SOCS) family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. CISH controls interleukin-2 signaling, and variations of CISH with certain SNPs are associated with susceptibility to bacteremia, tuberculosis and malaria. The human CISH gene is mapped to chromosome 3p21.3 by FISH. The mouse gene is tightly linked to the Gnai2 gene on chromosome 9, a region syntenic to human chromosome 3p21. CIS expression was upregulated by lipopolysaccharide (LPS) or Cryptosporidium parvum exposure, and this upregulation involved downregulation of MIR98 and LET7, which relieved MIR98- and LET7-mediated translational repression of CIS. Gain- and loss-of-function studies showed that CIS accelerated degradation of IKBA and enhanced NFKB activation in cholangiocytes in response to LPS stimulation or C parvum exposure.

Gene Full Name: cytokine inducible SH2 containing protein

Sequence Similarities: Contains 1 SH2 domain.

ID gène: 1154

UniProt: Q9NSE2

Pathways: Signalistation JAK/STAT, Response to Growth Hormone Stimulus