Dihydrofolate Reductase anticorps (AA 2-187) (PE)

N° du produit ABIN7985254

L’anticorps anti-Dihydrofolate Reductase Polyclonal Lapin est utilisé pour la détection de Dihydrofolate Reductase dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour Dihydrofolate Reductase anticorps (AA 2-187) (PE) (ABIN7985254)

Antigène: Dihydrofolate Reductase (DHFR)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Dihydrofolate Reductase est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Détail du produit anti-Dihydrofolate Reductase anticorps (PE)

Épitope: AA 2-187

Fonction: Anti-Dihydrofolate reductase (DHFR) Antibody PE Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human DHFR shares 90% amino acid (aa) sequence identity with both mouse,rat DHFR.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human DHFR recombinant protein (Position: V2-D187). Human DHFR shares 90% amino acid (aa) sequence identity with both mouse and rat DHFR.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur Dihydrofolate Reductase

Antigène: Dihydrofolate Reductase (DHFR)

Autre désignation: DHFR

Sujet:

Background: Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry. In humans, the DHFR enzyme is encoded by the DHFR gene. It is found in the q11→q22 region of chromosome 5. What's more, DHFR belongs to the dihydrofolate reductase family, and it converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. DHFR is the key enzyme in folate metabolism. In addition, DHFR catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

Gene Full Name: dihydrofolate reductase

Sequence Similarities: Belongs to the dihydrofolate reductase family.

ID gène: 1719

UniProt: P00374

Pathways: Mitotic G1-G1/S Phases