Dihydrofolate Reductase anticorps (AA 2-187) (Fluoro647)

N° du produit ABIN7985266

L’anticorps anti-Dihydrofolate Reductase Monoclonal Souris est utilisé pour la détection de Dihydrofolate Reductase dans des échantillons de Humain et Rat. Il a été validé pour FACS.

Aperçu rapide pour Dihydrofolate Reductase anticorps (AA 2-187) (Fluoro647) (ABIN7985266)

Antigène: Dihydrofolate Reductase (DHFR)

Reactivité: Humain, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Dihydrofolate Reductase est conjugé à/à la Fluoro647

Application: Flow Cytometry (FACS)

Clone: 3C8

Détail du produit anti-Dihydrofolate Reductase anticorps (Fluoro647)

Épitope: AA 2-187

Fonction: Anti-DHFR Antibody (monoclonal, 3C8) Fluoro647 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Homologie: Human DHFRshares90%aminoacid (aa)sequenceidentitywith both mouseandrat DHFR.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human DHFR recombinant protein (Position: V2-D187). Human DHFRshares90%aminoacid (aa)sequenceidentitywith both mouseandrat DHFR.

Isotype: IgG2b

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur Dihydrofolate Reductase

Antigène: Dihydrofolate Reductase (DHFR)

Autre désignation: DHFR

Sujet:

Background: SHC, also known as SHC1 (SHC-transforming protein 1) or SHCA, is a protein that in humans is encoded by the SHC1 gene. SCOP classifies the 3D structure as belonging to the SH2 domain family. This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: dihydrofolate reductase

ID gène: 1719

UniProt: P00374

Pathways: Mitotic G1-G1/S Phases