ERCC5 anticorps (AA 115-964) (Biotin)

N° du produit ABIN7985951

Cet anticorps anti-ERCC5 Polyclonal Lapin conjugué à Biotin (ABIN7985951) détecte spécifiquement ERCC5 dans WB, ELISA et IHC. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour ERCC5 anticorps (AA 115-964) (Biotin) (ABIN7985951)

Antigène: ERCC5 (DNA Repair Protein Complementing XP-G Cells (ERCC5))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERCC5 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-ERCC5 anticorps (Biotin)

Épitope: AA 115-964

Fonction: Anti-XPG/ERCC5 Antibody Biotin Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human XPG,ERCC5 shares 66.6% amino acid (aa) sequence identity with mouse XPG,ERCC5.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human XPG/ERCC5 recombinant protein (Position: K115-R964). Human XPG/ERCC5 shares 66.6% amino acid (aa) sequence identity with mouse XPG/ERCC5.

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur ERCC5

Antigène: ERCC5 (DNA Repair Protein Complementing XP-G Cells (ERCC5))

Autre désignation: ERCC5

Sujet:

Background: This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, cognitive disability, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene.

Gene Full Name: ERCC excision repair 5, endonuclease

ID gène: 2073

UniProt: P28715

Pathways: Réparation de l'ADN