ECD/SGT1 anticorps (AA 50-567) (Fluoro647)

N° du produit ABIN7987098

Cet anticorps Lapin Polyclonal détecte spécifiquement ECD/SGT1 dans FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour ECD/SGT1 anticorps (AA 50-567) (Fluoro647) (ABIN7987098)

Antigène: ECD/SGT1 (ECD) (Ecdysoneless Homolog (ECD))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ECD/SGT1 est conjugé à/à la Fluoro647

Application: Flow Cytometry (FACS)

Détail du produit anti-ECD/SGT1 anticorps (Fluoro647)

Épitope: AA 50-567

Fonction: Anti-SGT1/ECD Antibody Fluoro647 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human SGT1/ECD recombinant protein (Position: L50-Q567).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur ECD/SGT1

Antigène: ECD/SGT1 (ECD) (Ecdysoneless Homolog (ECD))

Autre désignation: ECD

Sujet:

Background: Protein SGT1 is a protein that in humans is encoded by the ECD gene. Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing.

Gene Full Name: ecdysoneless cell cycle regulator

ID gène: 11319

UniProt: O95905

Pathways: Regulation of Carbohydrate Metabolic Process