ECSIT anticorps (AA 83-339) (Fluoro594)

N° du produit ABIN7987115

Cet anticorps anti-ECSIT Polyclonal Lapin conjugué à Fluoro594 (ABIN7987115) détecte spécifiquement ECSIT dans FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour ECSIT anticorps (AA 83-339) (Fluoro594) (ABIN7987115)

Antigène: ECSIT

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ECSIT est conjugé à/à la Fluoro594

Application: Flow Cytometry (FACS)

Détail du produit anti-ECSIT anticorps (Fluoro594)

Épitope: AA 83-339

Fonction: Anti-ECSIT Antibody Fluoro594 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human ECSIT recombinant protein (Position: E83-S339).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur ECSIT

Antigène: ECSIT

Autre désignation: ECSIT

Sujet:

Background: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (ECSIT), also known as SITPEC, is a protein that in humans is encoded by the ECSIT gene. Activation of NF-kB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 to kinases such as IRAK and other intermediates such as TNF receptor associated factor (TRAF)-6. ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF)-6 in the TLR pathway. Recently however, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis, indicating the possibility of cross-talk between the TLR/IL-B and Bmp signaling pathways.

Gene Full Name: ECSIT signaling integrator

ID gène: 51295

UniProt: Q9BQ95

Pathways: Signalisation TLR, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interactome